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Some children may need adjustment in their medications, refinement in their technique, or instruction for proper administration!

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In still further embodiments, the isolated nucleic acids comprise a nucleotide sequence encoding modified revTetR proteins that exhibit the reverse phenotype in prokaryotes only at particular “permissive” temperatures, eg, at 37° C, while exhibiting essentially undetectable binding to a tet operator sequence at other “non-permissive” temperatures, eg.